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HTT-D3

Cat. No. M21225
HTT-D3  Structure
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Biological Activity

HTT-D3 is a potent and orally active regulator of Huntington (HTT) splicing. HTT-D3 acts by promoting pseudo-exons containing the premature termination codon (psiExon), resulting in HTT mRNA degradation and reduced HTT levels. HTT-D3 reduces p-glycoprotein (P-gp) efflux and can be used in Huntington's disease research.

Chemical Information
Molecular Weight 404.48
Formula C23H25FN6
CAS Number 2254502-89-9
Solubility (25°C) N/A
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

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Keywords: HTT-D3 supplier, P-glycoprotein, inhibitors, activators


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