HS-1371 inhibits ATP binding to prevent RIP3 enzymatic activity. HS-1371 shows an inhibitory effect on S227 auto-phosphorylation of RIP3 at the basal level. Inhibition of RIP3 kinase activity by HS-1371 blocks necrosome complex formation, showing disruption of MLKL recruitment. HS-1371 rescues cells from TNF-induced necroptosis.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Solubility||DMSO: ≥ 12 mg/mL|
HS-1371, a novel kinase inhibitor of RIP3-mediated necroptosis.
Park HH, et al. Exp Mol Med. 2018 Sep 20;50(9):125. PMID: 30237400.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2017 AbMole BioScience. All Rights Reserved.