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Cat. No. M9258
HS-1371 Structure
Size Price Availability Quantity
5mg USD 147 In stock
10mg USD 237 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

HS-1371 inhibits ATP binding to prevent RIP3 enzymatic activity. HS-1371 shows an inhibitory effect on S227 auto-phosphorylation of RIP3 at the basal level. Inhibition of RIP3 kinase activity by HS-1371 blocks necrosome complex formation, showing disruption of MLKL recruitment. HS-1371 rescues cells from TNF-induced necroptosis.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 384.47
Formula C24H24N4O
CAS Number 2158197-70-5
Purity >98%
Solubility DMSO: ≥ 12 mg/mL
Storage at -20°C

HS-1371, a novel kinase inhibitor of RIP3-mediated necroptosis.
Park HH, et al. Exp Mol Med. 2018 Sep 20;50(9):125. PMID: 30237400.

Related RIPK Products

GSK872 is a receptor interacting protein kinase-3 (RIP3) inhibitor, which inhibits kinase activity with an IC50 of 1.3 nM.


WEHI-345 is a potent and selective RIPK2 inhibitor with IC50 of 0.13 μM.

Abmole Inhibitor Catalog 2017

Keywords: HS-1371 supplier, RIPK, inhibitors

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