Homoharringtonine (HHT), a natural alkaloid produced by various Cephalotaxus species, has antileukemic activity in acute and chronic myelogenous leukemia. HHT treatment significantly increased apoptosis of K562 cells.HHT enhances the paracellular permeability of Caco-2 cell monolayers by modulating the protein expression and localization of claudin isoforms.HHT could be an active agent in the management of AML.HHT can also induce unanticipated effects in the gastrointestinal tract, such as diarrhea and nausea/vomiting, but the mechanism behind these adverse effects has not been clarified.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Solubility||DMSO 10 mM|
Homoharringtonine increases intestinal epithelial permeability by modulating specific claudin isoforms in Caco-2 cell monolayers.
Watari A, et al. Eur J Pharm Biopharm. 2015 Jan;89:232-8. PMID: 25513955.
Effectiveness of homoharringtonine (omacetaxine mepesuccinate) for treatment of acute myeloid leukemia: a meta-analysis of Chinese studies.
Kantarjian H, et al. Clin Lymphoma Myeloma Leuk. 2015 Jan;15(1):13-21. PMID: 25458084.
A comparative proteomic study of Homoharringtonine-induced apoptosis in leukemia K562 cells.
Zhou X, et al. Leuk Lymphoma. 2015 Jan;14:1-8. PMID: 25330443.
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