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Homo-PROTAC cereblon degrader 1 (OUN20985)

Cat. No. M10383
Homo-PROTAC cereblon degrader 1 (OUN20985) Structure
Synonym:

OUN20985

Size Price Availability Quantity
5mg USD 670  USD670 In stock
10mg USD 1050  USD1050 In stock
25mg USD 1900  USD1900 In stock
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Quality Control & Documentation
Biological Activity

Homo-PROTAC cereblon degrader 1 (OUN20985) is a potent and efficient cereblon (CRBN) degrader with minimal effects on IKZF1 and IKZF3.

Chemical Information
Molecular Weight 660.63
Formula C32H32N6O10
CAS Number 2244520-98-5
Solubility (25°C) DMSO ≥ 90 mg/mL
Storage 2-8°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Christian Steinebach, et al. ACS Chem Biol. Homo-PROTACs for the Chemical Knockdown of Cereblon

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Keywords: Homo-PROTAC cereblon degrader 1 (OUN20985), OUN20985 supplier, PROTAC, inhibitors, activators


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