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Hoechst 34580

Cat. No. M11515
Hoechst 34580 Structure
Synonym:

HOE 34580

Size Price Availability Quantity
5mg USD 59  USD59 In stock
10mg USD 88  USD88 In stock
50mg USD 232  USD232 In stock
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Quality Control & Documentation
Biological Activity

Hoechst 34580 (HOE 34580) is related to important small furrow binding dsDNA selective dyes Hoechst 33258 and Hoechst 33342, with a maximum excitation/emission wavelength of 392nm/440 nm (after binding to DNA), emitting blue fluorescence. For observation of nuclei, nucleic acids, stored at -25°C, away from light.

Chemical Information
Molecular Weight 451.57
Formula C27H29N7
CAS Number 23555-00-2
Solubility (25°C) Water ≥ 40 mg/mL
Storage -25°C, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] P D'Incecco, et al. Micron. A fluorescence in situ staining method for investigating spores and vegetative cells of Clostridia by confocal laser scanning microscopy and structured illuminated microscopy

[2] Nguyen Quoc Thai, et al. J Comput Aided Mol Des. Discovery of DNA dyes Hoechst 34580 and 33342 as good candidates for inhibiting amyloid beta formation: in silico and in vitro study

[3] Eugnia Nogueira, et al. Biochim Biophys Acta. Assessment of liposome disruption to quantify drug delivery in vitro

[4] Eugnia Nogueira, et al. Biomacromolecules. Peptide Anchor for Folate-Targeted Liposomal Delivery

[5] Wanhua Lei, et al. Chemphyschem. Host-guest interaction of Hoechst 34580 and Cucurbit[7]uril

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