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HIV-1 TAT Peptide TFA

Cat. No. M10207
HIV-1 TAT Peptide TFA Structure
Synonym:

HIV-1 tat Protein (47-57)

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5mg USD 230  USD230 In stock
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Quality Control & Documentation
Biological Activity

TAT TFA is a cell-penetrating peptide which derived from the transactivator of transcription (TAT) of human immunodeficiency virus (HIV-1).

Chemical Information
Molecular Weight 1673.85
Formula C66H119N32F3O16
CAS Number 191936-91-1 (free base)
Solubility (25°C) Water 50 mg/mL
Storage -20°C, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Andre Ziegler, et al. Biophys J. Interaction of the protein transduction domain of HIV-1 TAT with heparan sulfate: binding mechanism and thermodynamic parameters

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Keywords: HIV-1 TAT Peptide TFA, HIV-1 tat Protein (47-57) supplier, HIV Protease, inhibitors, activators


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