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HG-9-91-01

Cat. No. M9395
HG-9-91-01 Structure
Synonym:

SIK inhibitor 1

Size Price Availability Quantity
5mg USD 200  USD200 In stock
10mg USD 300  USD300 In stock
50mg USD 730  USD730 In stock
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Quality Control & Documentation
Biological Activity

HG-9-91-01 is a potent and highly selective salt-inducible kinase (SIK) inhibitor with IC50s of 0.92 nM, 6.6 nM and 9.6 nM for SIK1, SIK2 and SIK3 respectively. HG-9-91-01 demonstrates a strong correlation between the potency of SIK2 inhibition and enhanced IL-10 production. HG-9-91-01 treatment dose dependently increased mRNA expression of Pck1 and G6pc.

Chemical Information
Molecular Weight 567.68
Formula C32H37N7O3
CAS Number 1456858-58-4
Form Solid
Solubility (25°C) DMSO ≥ 90 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Patel K, et al. Nat Commun. The LKB1-salt-inducible kinase pathway functions as a key gluconeogenic suppressor in the liver.

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Keywords: HG-9-91-01, SIK inhibitor 1 supplier, Salt-inducible Kinase, inhibitors, activators


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