Hecogenin is a potent and highly selective inhibitor of UGT1A4 with an IC50 value of 1.5 μM. Hecogenin is a steroidal sapogenin which has been isolated from plants particularly from numerous Agave species.
| Molecular Weight | 430.62 |
| Formula | C27H42O4 |
| CAS Number | 467-55-0 |
| Solubility (25°C) | DMSO |
| Storage | 2-8°C, dry, protect from light, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Related Transferase Products |
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| POP-3MB
POP-3MB is an ICMT inhibitor (IC50: 2.5 μM). |
| P61A6
P61A6, a dihydropyrrole ring derivative and also a GGTase-I inhibitor, effectively inhibited tumor cell proliferation in a non-small cell lung cancer xenograft model, with IC50 values of 5-15 μmol/L for H358, H23 and H1507 cells. |
| Glabrol
Glabrol is a potent and non-competitive Acyl-coenzyme A: cholesterol acyltransferase (ACAT) inhibitor with an IC50 value of 24.6 μM for rat liver microsomal ACAT activity. |
| 3-Oxopomolic acid
Pomonic acid is a triterpenoid that significantly inhibits cholesterol ester accumulation and suppresses the acyl coenzyme A:cholesterol acyltransferase (ACAT) activity. |
| GST-IN-1
GST-IN-1 is a glutathione S-transferase (GST) inhibitor with IC50s of 1.55 μM (sjGST) and 2.02 μM (hGSTM2), respectively. |
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