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HCGRP-(8-37)

Cat. No. M13932
HCGRP-(8-37) Structure
Synonym:

Human α-CGRP (8-37)

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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

HCGRP-(8-37) is a human calcitonin gene-related peptide (hCGRP) fragment and also an antagonist of CGRP receptor.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 3125.59
Formula
CAS Number 119911-68-1
Purity >99%
Solubility Water ≥ 20 mg/mL
Storage at -20°C
References

[1] J Rinder, et al. Effects of hCGRP 8-37 and the NK1-receptor antagonist SR 140.333 on capsaicin-evoked vasodilation in the pig nasal mucosa in vivo

[2] Y Boulanger, et al. Structure of human calcitonin gene-related peptide (hCGRP) and of its antagonist hCGRP 8-37 as determined by NMR and molecular modeling

[3] L Bartho, et al. Studies on the mechanism of the contractile action of rat calcitonin gene-related peptide and of capsaicin on the guinea-pig ileum: effect of hCGRP (8-37) and CGRP tachyphylaxis

[4] T Chiba, et al. Calcitonin gene-related peptide receptor antagonist human CGRP-(8-37)

[5] C A Maggi, et al. Human alpha-calcitonin gene-related peptide-(8-37) as an antagonist of exogenous and endogenous calcitonin gene-related peptide

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Keywords: HCGRP-(8-37), Human α-CGRP (8-37) supplier, CGRP Receptor, inhibitors

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