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HA15

Cat. No. M6075
HA15 Structure
Size Price Availability Quantity
5mg USD 80 In stock
10mg USD 120 In stock
50mg USD 360 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

In vitro: HA15 induces ER stress leading to cancer cell death in vitro and overcomes BRAF inhibitor resistance in melanoma cells. In vivo: HA15 induces ER stress leading to cancer cell death and exhibits strong efficacy in xenograft mouse models with melanoma cells either sensitive or resistant to BRAF inhibitors.

Protocol
Cell Experiment
Cell lines A375 cells
Preparation method Electron microscopic images of A375 cells treated for 24 hr with HA15 displayed membrane blebs characteristic of apoptotic cells。
Concentrations 10 μM
Incubation time 24 h
Animal Experiment
Animal models female athymic nude mice
Formulation
Dosages 0.7 mg/mouse/day
Administration i.v.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 466.58
Formula C23H22N4O3S2
CAS Number 1609402-14-3
Purity >99%
Solubility 93 mg/mL in DMSO
Storage at -20°C
References

Effect of Hydroxyapatite porous characteristics on healing outcomes in rabbit posterolateral spinal fusion model.
Motomiya M, et al. Eur Spine J. 2007 Dec;16(12):2215-24. PMID: 17891422.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: HA15 supplier, inhibitors

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