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H3B-6527

Cat. No. M5242
H3B-6527 Structure
Size Price Availability Quantity
5mg USD 230 In stock
10mg USD 400 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

H3B-6527 (H3 Biomedicine) is a highly selective FGFR4 inhibitor with potent antitumour activity in FGF19 amplified cell lines and mice.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 629.54
Formula C29H34Cl2N8O4
CAS Number 1702259-66-2
Purity >98%
Solubility ≥ 6.3 mg/mL in DMSO
Storage at -20°C
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FGFR4-IN-1

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FGF-401

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: H3B-6527 supplier, FGFR, inhibitors

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