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GW791343 hydrochloride

Cat. No. M3233
GW791343 hydrochloride Structure
Size Price Availability
10mg USD 140 1-2 Weeks
50mg USD 540 1-2 Weeks
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

GW791343 hydrochloride is a non-competitive human P2X (7) receptor inhibitor with pIC50 of about 7.1. GW791343 hydrochloride exhibits negative allosteric effects at the human P2X (7) receptor but is a positive allosteric modulator of the rat P2X (7) receptor. GW791343 hydrochloride competitively interacted at the ATP binding site and so were probably negative allosteric modulators of the P2X (7) receptor. GW791343 hydrochloride increased responses to BzATP at the F95L mutant receptor, although the magnitude of this effect was not as marked as at the rat ECD, rat–human or domain 1 receptor.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 483.81
Formula C20H24F2N4O.3HCl
CAS Number 309712-55-8
Purity >98%
Solubility DMSO
Storage at -20°C
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Keywords: GW791343 hydrochloride supplier, P2 Receptor, inhibitors

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