Guggulsterone is a plant sterol from the gum fat of the Commiphora Wightii tree. It occurs in two heterogeneous forms, namely z-GS and E-GS. Guggulsterone is also a farnicol X receptor (FXR) antagonist that reduces CDCA-induced FXR activation. The IC50 of Z- and e-Guggulsterone is 17 and 15 μM, respectively.
| Molecular Weight | 312.45 |
| Formula | C21H28O2 |
| CAS Number | 95975-55-6 |
| Solubility (25°C) | DMSO : 20.83 mg/mL |
| Storage | 4°C, protect from light, dry, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[3] Ajaz A Bhat, et al. Nutr Metab (Lond). Potential therapeutic targets of Guggulsterone in cancer
[4] Takanori Yamada, et al. Adv Exp Med Biol. Guggulsterone and Its Role in Chronic Diseases
[5] Shishir Shishodia, et al. Curr Pharm Des. Guggulsterone for Chemoprevention of Cancer
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