Guanidine thiocyanate is a catalytic solvent. Guanidine thiocyanate is useful as a protein denaturing agent and nucleic acid protectant for DNA and RNA extraction from cells. It inactivates the virus for research.
| Molecular Weight | 118.16 |
| Formula | CH5N3.CHNS |
| CAS Number | 593-84-0 |
| Solubility (25°C) | Soluble in water |
| Storage | 2-8 °C |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Related Nucleic Acid Extraction and Purification Products |
|---|
| RNase A, bovine pancreas
RNase A, bovine pancreas cleaves RNA 3' to pyrimidines and cleaves RNA at each pyrimidine residue.Ribonuclease A catalyzes the hydrolysis of single-stranded RNA in the absence of metal ions or cofactors. |
| RNase Inhibitor, Murine
RNase Inhibitor, Murine specifically inhibits RNases A, B and C, thereby protecting RNA from degradation by these enzymes. |
| Universal nuclease |
| Recombinant DNase I (RNase Free) |
| Recombinant RNase R
Recombinant RNase R (E. coli) is a magnesium-dependent 3′→5′ exoribonuclease that can digest all linear RNAs but does not digest lariat or circular RNA structures. Most cellular RNAs will be digested completely by RNase R, with the exception of tRNAs, 5S RNA and intron lariats. |
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