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Guanfacine HCl

Cat. No. M5685
Guanfacine HCl Structure
Size Price Availability Quantity
10mg USD 60 In stock
50mg USD 180 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Guanfacine Hcl, an anti-hypertensive agent, is a selective α2A-adrenoceptor agonist with Kd of 31 nM and displays 60-fold selectivity over α2B-adrenoceptors.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 282.55
Formula C9H10Cl3N3O
CAS Number 29110-48-3
Purity >99%
Solubility 30 mg/mL in DMSO
Storage at -20°C
References

Extended-Release Guanfacine for Hyperactivity in Children With Autism Spectrum Disorder.
Scahill L, et al. Am J Psychiatry. 2015 Dec;172(12):1197-206. PMID: 26315981.

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  Catalog
Abmole Inhibitor Catalog 2017




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