GSK369796 is a 4-aminoquinoline drug candidate selected and developed as part of a public-private partnership between academics at Liverpool, MMV, and GSK pharmaceuticals. This molecule was rationally designed based on chemical, toxicological, pharmacokinetic, and pharmacodynamic considerations and was selected based on excellent activity against Plasmodium falciparum in vitro and rodent malaria parasites in vivo.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Solubility||10 mM in DMSO|
Antiviral activities of selected antimalarials against dengue virus type 2 and Zika virus.
Balasubramanian A, et al. Antiviral Res. 2017 Jan;137:141-150. PMID: 27889529.
Candidate selection and preclinical evaluation of N-tert-butyl isoquine (GSK369796), an affordable and effective 4-aminoquinoline antimalarial for the 21st century.
O'Neill PM, et al. J Med Chem. 2009 Mar 12;52(5):1408-15. PMID: 19222165.
(-)-p-Bromotetramisole Oxalate is a potent and non-specific alkaline phosphatase inhibitor.
Imidazole is a planar 5-membered ring. Imidazole is a highly polar compound.
Sodium tartrate has been used in organic synthesis to break up emulsions in aqueous workups. The compound is an ingredient of Fehling's solution and of the reagent Biuret (sc-239384). Fehling's solution tests for aldose and ketose functional is a component in the technique to produce micrometer sized aerosol particles.
Pyridoxine, also known as vitamin B6, is a form of vitamin B6 found commonly in food and used as dietary supplement. It is a cofactor for both glutamic acid decarboxylase and GABA transaminase.
Thiamine or vitamin B1 is a water-soluble vitamin of the B complex, its phosphate derivatives are involved in many cellular processes.
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