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GSK2801

Cat. No. M4909
GSK2801 Structure
Size Price Availability Quantity
10mM*1mL in DMSO USD 95  USD95 In stock
5mg USD 85  USD85 In stock
10mg USD 120  USD120 In stock
50mg USD 450  USD450 In stock
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Quality Control & Documentation
Biological Activity

In U2OS cells transfected with mutant BAZ2A (N1873F), GSK2801 (1 μM) accelerates FRAP half-recovery time by displacing BAZ2A from chromatin.

Chemical Information
Molecular Weight 371.45
Formula C20H21NO4S
CAS Number 1619994-68-1
Solubility (25°C) DMSO 74 mg/mL warmed
Water <1 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Chen P,et.al. J Med Chem. Discovery and Characterization of GSK2801, a Selective Chemical Probe for the Bromodomains BAZ2A and BAZ2B.

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Keywords: GSK2801 supplier, Epigenetic Reader Domain, inhibitors, activators


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