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GSK2801

Cat. No. M4909
GSK2801 Structure
Size Price Availability Quantity
5mg USD 80 In stock
10mg USD 110 In stock
50mg USD 440 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

In U2OS cells transfected with mutant BAZ2A (N1873F), GSK2801 (1 μM) accelerates FRAP half-recovery time by displacing BAZ2A from chromatin.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 371.45
Formula C20H21NO4S
CAS Number 1619994-68-1
Purity >99%
Solubility DMSO 74 mg/mL warmed
Water <1 mg/mL
Storage at -20°C
References

Discovery and Characterization of GSK2801, a Selective Chemical Probe for the Bromodomains BAZ2A and BAZ2B.
Chen P,et.al. J Med Chem. 2015 Apr 6. PMID: 25799074.

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  Catalog
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Keywords: GSK2801 supplier, Epigenetic Reader Domain, inhibitors

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