Free shipping on all orders over $ 500

GSK2593074A

Cat. No. M13394
GSK2593074A Structure
Synonym:

GSK'074

Size Price Availability
5mg USD 165  USD165 Out of stock
10mg USD 240  USD240 Out of stock
50mg USD 715  USD715 Out of stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

GSK2593074A is a necroptosis inhibitor that inhibits RIP1 and 3.

Chemical Information
Molecular Weight 465.57
Formula C27H23N5OS
CAS Number 1337531-06-2
Solubility (25°C) DMSO : 41.67 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Mitri K Khoury, et al. JVS Vasc Sci. GSK2593074A blocks progression of existing abdominal aortic dilation

[2] Ting Zhou, et al. Cell Death Dis. Identification of a novel class of RIP1/RIP3 dual inhibitors that impede cell death and inflammation in mouse abdominal aortic aneurysm models

Related RIPK Products
RIPK1-IN-12

RIPK1-IN-12 is a potent RIPK1 inhibitor.

DNL747

DNL747 is an ASK1 and RIPK1 inhibitor for studies related to Alzheimer's disease, amyotrophic lateral sclerosis, and multiple sclerosis.

DNL104

DNL104 is a RIPK1 inhibitor that can be used in Alzheimer's disease related studies.

mRNA-0184

mRNA-0184 is a relaxin mimetic and also a relaxin receptor-1 (RXFP1) agonist.

AZD-3427

AZD-3427 is an RXFP1 agonist that may be used in studies related to cardiovascular disease.

  Catalog
Abmole Inhibitor Catalog




Keywords: GSK2593074A, GSK'074 supplier, RIPK, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.