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GSK 4716

Cat. No. M6165
GSK 4716 Structure
Size Price Availability Quantity
10mg USD 67.5  USD75 In stock
50mg USD 288  USD320 In stock
100mg USD 508.5  USD565 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

GSK 4716 is a selective agonist with estrogen-related receptors ERRβ and ERRγ.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 282.33
Formula C17H18N2O2
CAS Number 101574-65-6
Purity >98%
Solubility 10 mM in DMSO
Storage at -20°C
References

Neurodevelopmental low-dose bisphenol A exposure leads to early life-stage hyperactivity and learning deficits in adult zebrafish.
Saili KS, et al. Toxicology. 2012 Jan 27;291(1-3):83-92. PMID: 22108044.

Efficient discovery of selective small molecule agonists of estrogen-related receptor gamma using combinatorial approach.
Kim Y, et al. J Comb Chem. 2009 Sep-Oct;11(5):928-37. PMID: 19746993.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: GSK 4716 supplier, Estrogen Receptor, inhibitors

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