Glycyrrhizic acid shows anti-inflammatory, antiulcerous and antiallergic effects.glycyrrhizic acid may have potential as a therapeutic agent in cerebral ischemia by preventing oxidative stress. Glycyrrhizic acid would be a promising carrier for the oral delivery of PTX.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
Bioavailability Enhancement of Paclitaxel via a Novel Oral Drug Delivery System: Paclitaxel-Loaded Glycyrrhizic Acid Micelles.
Yang FH, et al. Molecules. 2015 Mar 6;20(3):4337-56. PMID: 25756651.
The Neuroprotective Effect of Glycyrrhizic Acid on an Experimental Model of Focal Cerebral Ischemia in Rats.
Akman T, et al. Inflammation. 2015 Feb 17. PMID: 25687639.
[Effects of buspirone complex with glycyrrhizic acid on behavior of mice with anxious-depressive state].
Fomina MK, et al. Ross Fiziol Zh Im I M Sechenova. 2014 Jul;100(7):808-19. PMID: 25669106.
Protective Effects of Glycyrrhizic Acid and 18β-Glycyrrhetinic Acid against Cisplatin-Induced Nephrotoxicity in BALB/c Mice.
Wu CH, et al. J Agric Food Chem. 2015 Jan 26. PMID: 25588318.
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