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Glycyrrhizic acid

Cat. No. M3909
Glycyrrhizic acid Structure
Size Price Availability Quantity
10mg USD 80 In stock
50mg USD 160 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Glycyrrhizic acid shows anti-inflammatory, antiulcerous and antiallergic effects.glycyrrhizic acid may have potential as a therapeutic agent in cerebral ischemia by preventing oxidative stress. Glycyrrhizic acid would be a promising carrier for the oral delivery of PTX.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 822.94
Formula C42H62O16
CAS Number 1405-86-3
Purity >99%
Solubility DMSO 117mg/mL
Water 20mg/mL
Storage at -20°C
References

Bioavailability Enhancement of Paclitaxel via a Novel Oral Drug Delivery System: Paclitaxel-Loaded Glycyrrhizic Acid Micelles.
Yang FH, et al. Molecules. 2015 Mar 6;20(3):4337-56. PMID: 25756651.

The Neuroprotective Effect of Glycyrrhizic Acid on an Experimental Model of Focal Cerebral Ischemia in Rats.
Akman T, et al. Inflammation. 2015 Feb 17. PMID: 25687639.

[Effects of buspirone complex with glycyrrhizic acid on behavior of mice with anxious-depressive state].
Fomina MK, et al. Ross Fiziol Zh Im I M Sechenova. 2014 Jul;100(7):808-19. PMID: 25669106.

Protective Effects of Glycyrrhizic Acid and 18β-Glycyrrhetinic Acid against Cisplatin-Induced Nephrotoxicity in BALB/c Mice.
Wu CH, et al. J Agric Food Chem. 2015 Jan 26. PMID: 25588318.

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