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Glycol chitosan

Cat. No. M19968
Glycol chitosan Structure
Synonym:

Glycol chitin; deacetylated

Size Price Availability Quantity
100mg USD 48  USD48 In stock
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Quality Control & Documentation
Biological Activity

Glycol chitosan is a kind of chitosan derivative with hydrophilic glycol-branched. Glycol-chitosan enhances membrane permeability and lead in glycine Max Harosoy 63W cells. Glycol-chitosan has water solubility, biocompatibility and biodegradability. The inhibitory MIC values of ethylene glycol chitosan against Escherichia coli, Staphylococcus aureus and Salmonella enteritidis were 4 μg/mL, 32 μg/mL and <0.5 μg/mL, respectively.

Product Citations
Chemical Information
Molecular Weight 633.64
Formula C24H47N3O16
CAS Number 123938-86-3
Solubility (25°C) DMSO ≥ 40 mg/mL
Water 7.5 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Mi Zhang, et al. Mater Today Bio. Advanced application of stimuli-responsive drug delivery system for inflammatory arthritis treatment

[2] Ju Hee Ryu, et al. Adv Mater. Tumor-Targeting Glycol Chitosan Nanoparticles for Cancer Heterogeneity

[3] Fengming Lin, et al. Molecules . Glycol Chitosan: A Water-Soluble Polymer for Cell Imaging and Drug Delivery

[4] Fengming Lin, et al. Molecules. Glycol Chitosan: A Water-Soluble Polymer for Cell Imaging and Drug Delivery

[5] Zhong-Kai Cui, et al. Nat Commun. Microporous methacrylated glycol chitosan-montmorillonite nanocomposite hydrogel for bone tissue engineering

[6] Yongwhan Choi, et al. Expert Opin Drug Deliv. Tumor-targeting glycol chitosan nanocarriers: overcoming the challenges posed by chemotherapeutics

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Keywords: Glycol chitosan, Glycol chitin; deacetylated supplier, Anti-infection, inhibitors, activators


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