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Glycocholic acid

Cat. No. M9952
Glycocholic acid Structure
Size Price Availability Quantity
100mg USD 30  USD30 In stock
500mg USD 55  USD55 In stock
1g USD 80  USD80 In stock
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Quality Control & Documentation
Biological Activity

Glycocholic acid is a bile acid which has anticancer activity. Glycocholic acid increases the cytotoxicity of epirubicin, significantly increases the intracellular accumulation of epirubicin in Caco-2 cells.

Chemical Information
Molecular Weight 465.62
Formula C26H43NO6
CAS Number 475-31-0
Solubility (25°C) DMSO 90 mg/mL
methanol 90 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Y L Lo, et al. Eur J Pharm Sci. Inhibit multidrug resistance and induce apoptosis by using glycocholic acid and epirubicin

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