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Glucagon

Cat. No. M9312
Glucagon Structure
Size Price Availability Quantity
5mg USD 177.3  USD197 In stock
10mg USD 279  USD310 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Glucagon is a peptide hormone that helps regulate the blood sugar (glucose) levels in the body. Glucagon binds to the glucagon receptors, the liver cells convert the glycogen into individual glucose molecules and release them into the bloodstream, in a process known as glycogenolysis.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 3482.75
Formula C153H225N43O49S
CAS Number 16941-32-5
Purity >99%
Solubility DMSO 10 mM
Storage -20°C, protect from light, dry, sealed
References

Chemical Hybridization of Glucagon and Thyroid Hormone Optimizes Therapeutic Impact for Metabolic Disease.
Finan B, et al. Cell. 2016 Oct 20;167(3):843-857.e14. PMID: 27720451.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Glucagon supplier, Glucagon Receptor, inhibitors

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