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GL3

Cat. No. M19462
GL3 Structure
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Quality Control
  • Current batch:
  • Purity >95%
  • COA
  • MSDS
Biological Activity

GL3

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight
Formula C33H53NO6
CAS Number 60037-39-0
Purity >95%
Solubility
Storage at -20°C
References

[1] Yuping Qiu, et al. Proc Natl Acad Sci U S A. EIN3 and RSL4 interfere with an MYB-bHLH-WD40 complex to mediate ethylene-induced ectopic root hair formation in Arabidopsis

[2] Xiao-Chen Wang, et al. Plant J. Arabidopsis MYB4 plays dual roles in flavonoid biosynthesis

[3] Emma H McCafferty, et al. Drugs. Migalastat: A Review in Fabry Disease

[4] Duo Xia, et al. Mol Plant. GL3.3, a Novel QTL Encoding a GSK3/SHAGGY-like Kinase, Epistatically Interacts with GS3 to Produce Extra-long Grains in Rice

[5] Syed Rizwan A. Bokhari, et al. Fabry Disease

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