GK921 showed cytotoxicity to RCC (average GI50 in eight RCC cell lines: 0.905 μM). A single treatment with GK921 almost completely reduced tumor growth by stabilizing p53 in the ACHN and CAKI-1 preclinical xenograft tumor models. GK921 rescues p53 levels and consequently induces apoptosis; a concentration-dependent increase in cleaved poly(ADP-ribose) polymerase (c-PARP) and p53 levels is observed.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Solubility||DMSO: ≥ 25 mg/mL|
Discovery of a novel target for renal cell carcinoma: transglutaminase 2.
Kang JH, et al. Cell Death Dis. 2016 Apr 21;7:e2200. PMID: 27100894.
Renal cell carcinoma escapes death by p53 depletion through transglutaminase 2-chaperoned autophagy.
Kang JH, et al. Cell Death Dis. 2016 Mar 31;7:e2163. PMID: 27031960.
Transglutaminase 2 inhibitor abrogates renal cell carcinoma in xenograft models.
Ku BM, et al. J Cancer Res Clin Oncol. 2014 May;140(5):757-67. PMID: 24610445.
YM-90709 is an interleukin-5 receptor antagonist.
HUHS015 is a potent PCA-1/ALKBH3 inhibitor, which continuously administering HUHS015 significantly suppressed the growth of DU145 cells.
1-methoxy PMS is stable electron-transport mediator between NAD(P)H and tetrazolium dyes.
Erythropoietin (EPO) is a glycoprotein cytokine secreted by the kidney in response to cellular hypoxia.
Interferon gamma (IFNγ) is a dimerized soluble cytokine that is the only member of the type II class of interferons.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2017 AbMole BioScience. All Rights Reserved.