Ginkgetin is a natural biflavonoid isolated from leaves of Ginkgo biloba L. with effects of anti-inflammation and anticancer activity. Ginkgetin inhibits COX-2 dependent phases of prostaglandin D(2) (PGD(2)) generation in bone marrow-derived mast cells (BMMC) in a concentration-dependent manner with IC(50) values of 0.75 microM. Ginkgetin consistently inhibited the production of leukotriene C(4) (LTC(4)) in a dose dependent manner, with an IC(50) value of 0.33 microM. Ginkgetin also inhibited degranulation reaction in a dose dependent manner, with an IC(50) value of 6.52 microM.
In vivo, Ginkgetin inhibited tumor growth in xenografted nude mice and down-regulated p-STAT3Tyr705 and survivin in tumor tissues. At total doses of 1,000 microg/site on the dorsal skin (15 mm x 15 mm), ginkgetin inhibited prostaglandin E2 production by 65.6 % along with a marked suppression of COX-2 induction.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Solubility||DMSO ≥ 30 mg/mL|
|Storage||2-8°C, dry, protect from light, sealed|
Ginkgetin Inhibits the Growth of DU-145 Prostate Cancer Cells Through Inhibition of Signal Transducer and Activator of Transcription 3 Activity
Yoon Jung Jeon, et al. Cancer Sci. 2015 Apr;106(4):413-20. PMID: 25611086.
Ginkgetin Induces Apoptosis via Activation of Caspase and Inhibition of Survival Genes in PC-3 Prostate Cancer Cells
Ok Heui You, et al. Bioorg Med Chem Lett. 2013 May 1;23(9):2692-5. PMID: 23523142.
Ginkgetin, a Biflavone From Ginko Biloba Leaves, Inhibits cyclooxygenases-2 and 5-lipoxygenase in Mouse Bone Marrow-Derived Mast Cells
Jong Keun Son, et al. Biol Pharm Bull. 2005 Dec;28(12):2181-4. PMID: 16327145.
|Related Others Products|
Saponins are a class of chemical compounds of glycosides found in particular abundance in various plant species. Saponins possesses antiviral, antifungal, antitumor, anti-inflammatory, hypoglycemic and hypocholesterolemic effects.
Coixol is a natural product extracted from Coix Lachryma-Jobi var. ma-yuen.
Brassinolide is a plant steroid that promotes cell elongation and cell devision and thus regulates plant growth and development.
Hastatoside is isolated from Verbena species and exhibits various biological activities including sleep-promoting.
Ademetionine(S-adenosyl-l-methionine; SAMe) is a naturally-occurring substance which is a major source of methyl groups in the brain.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.