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Ginkgetin

Cat. No. M9574
Ginkgetin Structure
Size Price Availability Quantity
5mg USD 275 In stock
10mg USD 461 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Ginkgetin is a natural biflavonoid isolated from leaves of Ginkgo biloba L. with effects of anti-inflammation and anticancer activity. Ginkgetin inhibits COX-2 dependent phases of prostaglandin D(2) (PGD(2)) generation in bone marrow-derived mast cells (BMMC) in a concentration-dependent manner with IC(50) values of 0.75 microM. Ginkgetin consistently inhibited the production of leukotriene C(4) (LTC(4)) in a dose dependent manner, with an IC(50) value of 0.33 microM. Ginkgetin also inhibited degranulation reaction in a dose dependent manner, with an IC(50) value of 6.52 microM.

In vivo, Ginkgetin inhibited tumor growth in xenografted nude mice and down-regulated p-STAT3Tyr705 and survivin in tumor tissues. At total doses of 1,000 microg/site on the dorsal skin (15 mm x 15 mm), ginkgetin inhibited prostaglandin E2 production by 65.6 % along with a marked suppression of COX-2 induction.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 566.51
Formula C32H22O10
CAS Number 481-46-9
Purity >99%
Solubility DMSO ≥ 30 mg/mL
Storage 2-8°C, dry, protect from light, sealed
References

Ginkgetin Inhibits the Growth of DU-145 Prostate Cancer Cells Through Inhibition of Signal Transducer and Activator of Transcription 3 Activity
Yoon Jung Jeon, et al. Cancer Sci. 2015 Apr;106(4):413-20. PMID: 25611086.

Ginkgetin Induces Apoptosis via Activation of Caspase and Inhibition of Survival Genes in PC-3 Prostate Cancer Cells
Ok Heui You, et al. Bioorg Med Chem Lett. 2013 May 1;23(9):2692-5. PMID: 23523142.

Ginkgetin, a Biflavone From Ginko Biloba Leaves, Inhibits cyclooxygenases-2 and 5-lipoxygenase in Mouse Bone Marrow-Derived Mast Cells
Jong Keun Son, et al. Biol Pharm Bull. 2005 Dec;28(12):2181-4. PMID: 16327145.

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