Gibberellic acid (GA), a plant hormone stimulating plant growth and development, is a tetracyclic di-terpenoid compound. Abscisic acid and GA3 have been found to affect sexual differentiation and other physiological characteristics in mice. Gibberellic acid is tested by various routes in mice for its acute toxicity and found to be essentially nontoxic. Both subacute toxicity in mice and subchronic toxicity in dogs and rats show the compound to be asymptomatic and free of pathologic changes, histologically. The highest observed nontoxic (and asymptomatic) doses in mice as determined by acute toxicity testing are as follows: 4 Gm./Kg., intravenously; 15 Gm./Kg., orally; and 2 Gm./Kg., intraperitoneally.
| Molecular Weight | 346.37 |
| Formula | C19H22O6 |
| CAS Number | 77-06-5 |
| Solubility (25°C) | DMSO: ≥ 30 mg/mL |
| Storage | 2-8°C, protect from light |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[2] Jenia Binenbaum, et al. Gibberellin Localization and Transport in Plants
[3] Takeshi Ito, et al. DELLA-dependent and -independent gibberellin signaling
[4] Jean-Michel Davire, et al. Gibberellin signaling in plants
[5] Shinjiro Yamaguchi. Gibberellin metabolism and its regulation
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