Ghrelin (human) Acetate is an endogenous agonist peptide for the ghrelin (GHS) receptor. Ghrelin (human) Acetate stimulates release of growth hormone from the pituitary gland and regulates feeding, appetite, growth and energy homeostasis.
| CAS Number | 258279-04-8 (free base) |
| Solubility (25°C) | Soluble in water |
| Storage | -20°C, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[2] Shigehisa Yanagi, et al. Cell Metab. The Homeostatic Force of Ghrelin
[6] Yuanjie Mao, et al. Hypertension. Ghrelin as a treatment for cardiovascular diseases
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