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Genistein

Cat. No. M2255
Genistein Structure
Synonym:

NPI 031L

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
10mg USD 22  USD22 In stock
100mg USD 46  USD46 In stock
500mg USD 86  USD86 In stock
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Quality Control & Documentation
Biological Activity

Genistein is a highly specific inhibitor of protein tyrosine kinase (PTK) which blocks the mitogenic effect mediated by EGF on NIH-3T3 cells with IC50 of 12μM or by insulin with IC50 of 19 μM. Genistein inhibits protein tyrosine kinases including epidermal growth factor receptor kinase. Genistein also binds to PPARγ and estrogen receptors and acts as an agonist at GPR30.

Product Citations
Chemical Information
Molecular Weight 270.24
Formula C15H10O5
CAS Number 446-72-0
Solubility (25°C) DMSO 54 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Linda Yu, et al. Genistein: Dual Role in Women's Health

[2] Prakash Thangavel, et al. Genistein as Potential Therapeutic Candidate for Menopausal Symptoms and Other Related Diseases

[3] Neha Jaiswal, et al. An Overview on Genistein and its Various Formulations

[4] Vidya Mukund, et al. Genistein: Its role in metabolic diseases and cancer

[5] Carmela Spagnuolo, et al. Genistein and cancer: current status, challenges, and future directions

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Keywords: Genistein, NPI 031L supplier, EGFR/HER2, inhibitors, activators


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