Genistein is a highly specific inhibitor of protein tyrosine kinase (PTK) which blocks the mitogenic effect mediated by EGF on NIH-3T3 cells with IC50 of 12μM or by insulin with IC50 of 19 μM. Genistein inhibits protein tyrosine kinases including epidermal growth factor receptor kinase. Genistein also binds to PPARγ and estrogen receptors and acts as an agonist at GPR30.
Biomaterials. 2021 Aug;275:120958.
Tumor progress intercept by intervening in Caveolin-1 related intercellular communication via ROS-sensitive c-Myc targeting therapy
Genistein purchased from AbMole
Molecular Weight | 270.24 |
Formula | C15H10O5 |
CAS Number | 446-72-0 |
Solubility (25°C) | DMSO 54 mg/mL |
Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[1] Linda Yu, et al. Genistein: Dual Role in Women's Health
[3] Neha Jaiswal, et al. An Overview on Genistein and its Various Formulations
[4] Vidya Mukund, et al. Genistein: Its role in metabolic diseases and cancer
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