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Genipin

Cat. No. M3327
Genipin Structure
Synonym:

(+)-Genipin

Size Price Availability Quantity
10mM*1mL in DMSO USD 70  USD70 In stock
10mg USD 40  USD40 In stock
50mg USD 85  USD85 In stock
100mg USD 120  USD120 In stock
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Quality Control & Documentation
Biological Activity

Genipin is an active aglycone derived from an iridoid glycoside called geniposide, which is found in the fruit of Gardenia jasminoides Ellis. Genipin is a hydrolytic product of geniposide. Genipin has been used in traditional Chinese medicine. Genipin is used in traditional Chinese medicine to relieve the symptoms of type 2 diabetes. Genipin is an excellent natural cross-linker for proteins, collagen, gelatin, and chitosan cross-linking. Genipin has a low acute toxicity, with LD50 i.v. 382 mg/kg in mice. Therefore, much less toxic than glutaraldehyde and many other commonly used synthetic cross-linking regents. Genipin is also used for pharmaceutical purposes, such as choleretic action for liver diseases control. Furthermore,genipin can be used as a cross-linking agent for immobilized enzyme, the regulating agent for compound delivery, the raw materials for gardenia blue pigment preparation,as well as the intermediate for alkaloid synthetic etc. Genipin is a naturally occurring material that shows great potential as a use in biomaterials and also as a fingerprint reagent.

Chemical Information
Molecular Weight 226.23
Formula C11H14O5
CAS Number 6902-77-8
Solubility (25°C) DMSO 35 mg/mL
Storage 2-8°C, protect from light
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Elena Koudouna, et al. Genipin in an Ex Vivo Corneal Model of Bacterial and Fungal Keratitis

[2] Christopher Donovan, et al. Genipin Delays Corneal Stromal Enzymatic Digestion

[3] Yibin Yu, et al. Genipin-cross-linked hydrogels based on biomaterials for drug delivery: a review

[4] Xiaofei Fan, et al. Therapeutic potential of genipin in various acute liver injury, fulminant hepatitis, NAFLD and other non-cancer liver diseases: More friend than foe

[5] Muthu K Shanmugam, et al. Potential role of genipin in cancer therapy

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Keywords: Genipin, (+)-Genipin supplier, Autophagy, inhibitors, activators


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