GDC-2394 is an oral inhibitor of NLRP3 inflammasome. The NLRP3 inflamome, the best studied and most characterized, also inhibits IL-1β with IC50 of 0.4 μM (human IL-1β) and 0.1 μM (mouse IL-1β).
| Molecular Weight | 431.51 |
| Formula | C20H25N5O4S |
| CAS Number | 2238822-07-4 |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Related NLR Products |
|---|
| Selnoflast
Selnoflast is an orally effective inhibitor of NLRP3 for studies related to systemic inflammation. |
| (±)11(12)-EET
(±)11(12)-EET is an NLRP3 inflammatory vesicle inhibitor that can be used in studies related to anti-inflammation, neovascularization, and cardioprotection. |
| Antcin A
Antcin A is an NLRP3 inhibitor that inhibits the assembly and activation of NLRP3 inflammatory vesicles. In addition, Antcin A inhibits pyroptosis of Kupffer cells and has hepatoprotective activity.Antcin A can be used in inflammation-related studies. |
| ADS032
ADS032 is a dual inhibitor of NLRP1 and NLRP3 that rapidly, reversibly and stably inhibits inflammasome formation and reduces NLPR1 and NLRP3 activation of human-derived macrophages and bronchial epithelial cells to secrete and mature IL-1β and TNF-α, and reduces NLRP3-induced ASC speck formation. In addition, ADS032 protects mice from the deadly influenza A virus, reduces lung inflammation and improves survival. |
| Emlenoflast sodium
Emlenoflast sodium is a sulfonylurea and a potent and selective inhibitor of NLRP3 inflammatory vesicles with an IC50 value of less than 100 nM.Emlenoflast sodium can be used in the study of inflammatory diseases. |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.
