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Garcinone E

Cat. No. M10671
Garcinone E Structure
Synonym:

Garcinone-E

Size Price Availability
5mg USD 937.5  USD937.5 4-7 Days
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Garcinone E is the most active xanthone from mangosteen, which has potent cytotoxic effect against hepatocellular carcinoma cell lines. Garcinone E might inhibit metastasis of an oral cancer cell line by blocking invasion, migration and MMP production. Garcinone E (GE) significantly inhibited the proliferation in HEY, A2780, and A2780/Taxol cells. It induced endoplasmic reticulum (ER) stress and activated the protective inositol-requiring kinase (IRE)-1α pathway. Moreover, GE eliminated the migratory ability of HEY cells by reducing the expression of RhoA and Rac. It also blocked the invasion, which might be related to downregulation of matrix metalloproteinases (MMPs), i.e., MMP-9 and MMP-2, and upregulation of tissue inhibitors of metalloproteinase (TIMP) -1 and TIMP-2.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 464.55
Formula C28H32O6
CAS Number 112649-21-5
Purity >98%
Solubility DMSO 10 mM
Storage 2-8°C, dry, sealed
References

[1] Linli Yang, et al. AMB Express . Garcinone-E exhibits anticancer effects in HeLa human cervical carcinoma cells mediated via programmed cell death, cell cycle arrest and suppression of cell migration and invasion

[2] Sheeja K, et al. Asian Pac J Cancer Prev . Antimetastatic Potential of Garcinone E in Human Oral Cancer Cells

[3] Xiao-Huang Xu, et al. Sci Rep . Garcinone E induces apoptosis and inhibits migration and invasion in ovarian cancer cells

[4] Chi-Kuan Ho, et al. Planta Med . Garcinone E, a xanthone derivative, has potent cytotoxic effect against hepatocellular carcinoma cell lines

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Garcinone E, Garcinone-E supplier, inhibitors

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