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Cat. No. M1812
GANT58 Structure


Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
5mg USD 60 In stock
10mg USD 90 In stock
50mg USD 330 In stock
100mg USD 533 In stock
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Quality Control
  • Current batch:
  • Purity 98.90%
  • COA
  • MSDS
Biological Activity

GANT58 is a cell-permeable GLI antagonist that inhibits GLI1-induced transcription (IC50 = 5 μM). Acts as a blocker of Hedgehog (Hh) pathway downstream of SMO and SUFU causing Gli1 nuclear accumulation. It also targets Gli-mediated gene transactivation (IC50 ~ 5 µM in SAG-stimulated Shh-L2 cells) and displays anti-proliferative and antitumor activity in vivo.

Customer Product Validations & Biological Datas
Source Biochimie (2014). Figure 3. GANT58
Method CCK8 assays
Cell Lines T-ALL cells
Concentrations 5 and 10 μM
Incubation Time 48 h
Results Furthermore, incubation of CCRFeCEM with 10 μM GANT58 for 48 h caused an increase in the percentage of cells in G1 and S phase and a decrease in the percentage of cells in G2/M phase relative to controls
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 392.48
Formula C24H16N4S
CAS Number 64048-12-0
Purity 98.90%
Solubility DMSO 20 mM
Storage at -20°C

Molecular pathways: the role of primary cilia in cancer progression and therapeutics with a focus on Hedgehog signaling.
Hassounah NB, et al. Clin Cancer Res. 2012 May 1;18(9):2429-35. PMID: 22415315.

Small-molecule modulators of the Sonic Hedgehog signaling pathway.
Stanton BZ, et al. Mol Biosyst. 2010 Jan;6(1):44-54. PMID: 20024066.

Hedgehog target genes: mechanisms of carcinogenesis induced by aberrant hedgehog signaling activation.
Katoh Y, et al. Curr Mol Med. 2009 Sep;9(7):873-86. PMID: 19860666.

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Keywords: GANT58, NSC75503 supplier, Hedgehog, inhibitors

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