Free shipping on all orders over $ 500

GANT58

Cat. No. M1812

GANT58 Structure

Synonym: NSC75503

Size Price Availability Quantity
10mg USD 90 In stock
50mg USD 320 In stock
100mg USD 425 In stock
Bulk Inquiry?

Quality Control
Biological Activity

GANT58 is a cell-permeable GLI antagonist that inhibits GLI1-induced transcription (IC50 = 5 μM). Acts as a blocker of Hedgehog (Hh) pathway downstream of SMO and SUFU causing Gli1 nuclear accumulation. It also targets Gli-mediated gene transactivation (IC50 ~ 5 µM in SAG-stimulated Shh-L2 cells) and displays anti-proliferative and antitumor activity in vivo.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 392.48
Formula C24H16N4S
CAS Number 64048-12-0
Purity 98.90%
Solubility DMSO
Ethanol
Storage at -20°C
References

Molecular pathways: the role of primary cilia in cancer progression and therapeutics with a focus on Hedgehog signaling.
Hassounah NB, et al. Clin Cancer Res. 2012 May 1;18(9):2429-35. PMID: 22415315.

Small-molecule modulators of the Sonic Hedgehog signaling pathway.
Stanton BZ, et al. Mol Biosyst. 2010 Jan;6(1):44-54. PMID: 20024066.

Hedgehog target genes: mechanisms of carcinogenesis induced by aberrant hedgehog signaling activation.
Katoh Y, et al. Curr Mol Med. 2009 Sep;9(7):873-86. PMID: 19860666.

Related Hedgehog Products
Smoothened Agonist (SAG) HCl

Smoothened Agonist (SAG) HCl is a cell-permeable Smoothened (Smo) agonist with EC50 of 3 nM in Shh-LIGHT2 cells.

LDE225 Diphosphate

LDE225 Diphosphate is a Smoothened (Smo) antagonist, inhibiting Hedgehog (Hh) signaling with IC50 of 1.3 nM (mouse) and 2.5 nM (human), respectively.

Jervine

Jervine is a naturally occuring steroidal alkaloid that causes cyclopia by blocking sonic hedgehog signaling.

GANT61

GANT61 is an inhibitor for GLI1 as well as GLI2-induced transcription, inhibits hedgehog with IC50 of 5 μM.

PF-5274857

PF-5274857 is a novel Smoothened antagonist, inhibits Hedgehog signaling with IC50 and Ki values of 5.8 nM and 4.6 nM, respectively.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: GANT58, NSC75503 supplier, Hedgehog, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2017 AbMole BioScience. All Rights Reserved.