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Ganciclovir sodium

Cat. No. M19956
Ganciclovir sodium Structure
Size Price Availability Quantity
100mg USD 72  USD72 In stock
1g USD 115  USD115 In stock
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Quality Control & Documentation
Biological Activity

Ganciclovir sodium is an antiviral medication used to treat cytomegalovirus (CMV) infections

Chemical Information
Molecular Weight 277.21
Formula C9H12N5NaO4
CAS Number 107910-75-8
Form Solid
Solubility (25°C) DMSO 55 mg/mL
Water 55 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Raymund R Razonable. Curr Pharm Des. Cytomegalovirus in Solid Organ Transplant Recipients: Clinical Updates, Challenges and Future Directions

[2] Abdullah A Al-Badr, et al. Profiles Drug Subst Excip Relat Methodol. Ganciclovir

[3] C N Kotton. Am J Transplant. CMV: Prevention, Diagnosis and Therapy

[4] G C Visor, et al. Am J Hosp Pharm. Stability of ganciclovir sodium (DHPG sodium) in 5% dextrose or 0.9% sodium chloride injections

[5] W Brooks. Aust Nurses J. Ganciclovir

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