Gallic acid is an antiinflammatory and Cox inhibitor substance found in plants and has been shown to Induce apoptosis in human lung cancer cells. Gallic acid seems to have anti-fungal and anti-viral properties. Gallic acid acts as a antioxidant and helps to protect our cells against oxidative damage. Gallic acid was found to show cytotoxicity against cancer cells, without harming healthy cells. Gallic acid is used a remote astringent in cases of internal haemorrhage. Gallic acid is also used to treat albuminuria and diabetes. Some ointment to treat psoriasis and external haemorrhoids contain gallic acid.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Solubility||Soluble in water to 50 mM and in ethanol|
COX-2 structural analysis and docking studies with gallic acid structural analogues.
Amaravani M, et al. Springerplus. 2012 Dec;1(1):58. PMID: 23483789.
Oral treatment with gallic acid and quercetin alleviates lindane-induced cardiotoxicity in rats.
Vijaya Padma V, et al. Can J Physiol Pharmacol. 2013 Feb;91(2):134-40. PMID: 23458197.
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