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Galangin

Cat. No. M4699
Galangin Structure
Synonym:

3,5,7-Trihydroxyflavone

Size Price Availability Quantity
25mg USD 80  USD80 In stock
50mg USD 140  USD140 In stock
100mg USD 215  USD215 In stock
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Quality Control
Biological Activity

Galangin (Norizalpinin) is a regulator of arylhydrocarbon receptors and also inhibits the activity of CYP1A1.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 270.24
Formula C15H10O5
CAS Number 548-83-4
Purity 99.82%
Solubility DMSO ≥ 100 mg/mL
Storage at -20°C
References

[1] Shailima Rampogu, et al. A comprehensive review on chemotherapeutic potential of galangin

[2] Kok-Tong Tan, et al. Galangin ameliorates experimental autoimmune encephalomyelitis in mice via modulation of cellular immunity

[3] Xue Guan, et al. Galangin attenuated cerebral ischemia-reperfusion injury by inhibition of ferroptosis through activating the SLC7A11/GPX4 axis in gerbils

[4] Yang Kong, et al. The Natural Flavonoid Galangin Elicits Apoptosis, Pyroptosis, and Autophagy in Glioblastoma

[5] Hae Nim Lee, et al. Anti‑inflammatory effect of quercetin and galangin in LPS‑stimulated RAW264.7 macrophages and DNCB‑induced atopic dermatitis animal models

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Keywords: Galangin, 3,5,7-Trihydroxyflavone supplier, Cytochrome P450 (e.g. CYP17), inhibitors

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