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G-5555 hydrochloride

Cat. No. M13707
G-5555 hydrochloride Structure
Size Price Availability
5mg USD 110  USD110 4-7 Days
10mg USD 160  USD160 4-7 Days
25mg USD 360  USD360 4-7 Days
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

G-5555 hydrochloride is a potent and selective p21-activated kinase 1 (PAK1) inhibitor with a Ki of 3.7 nM.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 529.42
Formula
CAS Number
Purity >99%
Solubility DMSO 90 mg/mL
Water 16.67 mg/mL
Storage 2-8°C, dry, sealed
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  Catalog
Abmole Inhibitor Catalog




Keywords: G-5555 hydrochloride supplier, PAK, inhibitors

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