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Fupentixol dihydrochloride

Cat. No. M6196
Fupentixol dihydrochloride Structure
Size Price Availability Quantity
5mg USD 180 In stock
10mg USD 280 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

The dopamine antagonist, Fupentixol did not affect the ghrelin-induced food intake. During the first half of the dark phase Fupentixol significantly increased the intake of standard chow, whereas a decrease in food intake was observed during the second part of the dark phase.

Protocol
Cell Experiment
Cell lines
Preparation method
Concentrations
Incubation time
Animal Experiment
Animal models Male Sprague–Dawley rats
Formulation sterile doubly distilled water
Dosages 0.25 mg/kg
Administration i.p.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 507.44
Formula C23H27Cl2F3N2OS
CAS Number 2413-38-9
Purity >98%
Solubility 10 mM in DMSO
Storage at -20°C
References

Effect of cis-(Z)-flupentixol on DPPC membranes in the presence and absence of cholesterol.
Yonar D, et al. Chem Phys Lipids. 2016 Jun;198:61-71. PMID: 27282777.

The dopamine antagonist flupentixol does not alter ghrelin-induced food intake in rats.
Engster KM, et al. Neuropeptides. 2015 Oct;53:19-27. PMID: 26329764.

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  Catalog
Abmole Inhibitor Catalog 2017




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