The dopamine antagonist, Fupentixol did not affect the ghrelin-induced food intake. During the first half of the dark phase Fupentixol significantly increased the intake of standard chow, whereas a decrease in food intake was observed during the second part of the dark phase.
|Animal models||Male Sprague–Dawley rats|
|Formulation||sterile doubly distilled water|
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Solubility||10 mM in DMSO|
Effect of cis-(Z)-flupentixol on DPPC membranes in the presence and absence of cholesterol.
Yonar D, et al. Chem Phys Lipids. 2016 Jun;198:61-71. PMID: 27282777.
The dopamine antagonist flupentixol does not alter ghrelin-induced food intake in rats.
Engster KM, et al. Neuropeptides. 2015 Oct;53:19-27. PMID: 26329764.
Elamipretide, also known as MTP-131, is a cardiolipin peroxidase inhibitor and mitochondria-targeted peptide.
Hexacosanoic acid is a long-chain fatty acid related to various diseases such as adrenoleukodystrophy (ALD), adrenomyeloneuropathy (AMN) and atherosclerosis.
Corn oil, extracted from the germ of corn, can be used as a carrier for drug molecules and has anti-tumor activity.
Palosuran, also known as ACT-058362, is a Urotensin-II receptor antagonist with an IC50 of 3.6±0.2 nM.
Dithiothreitol (DTT) is the common name for a small-molecule redox reagent known as Cleland's reagent; as a reducing or "deprotecting" agent for thiolated DNA.
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