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Friedelin

Cat. No. M14313
Friedelin Structure
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Biological Activity

Friedelin is isolated from isolated from the leaves of Maytenus ilicifolia(Mart). Friedelin is a noncompetitive inhibitor of CYP3A4 with IC50 and Kivalues of 10.79  μM and 6.16  μM, respectively. Friedelin is also a competitive inhibitor of CYP2E1 with IC50 and Ki values of 22.54  μM and 18.02 μM, respectively.

Chemical Information
Molecular Weight 426.72
CAS Number 559-74-0
Storage -20°C, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Bei Shi, et al. Revealing the Mechanism of Friedelin in the Treatment of Ulcerative Colitis Based on Network Pharmacology and Experimental Verification

[2] Christudas Sunil, et al. Friedelin exhibits antidiabetic effect in diabetic rats via modulation of glucose metabolism in liver and muscle

[3] Wei Chang, et al. Friedelin inhibits the growth and metastasis of human leukemia cells via modulation of MEK/ERK and PI3K/AKT signalling pathways

[4] Thas B Alves, et al. Friedelin in Maytenus ilicifolia Is Produced by Friedelin Synthase Isoforms

[5] Jin-Ah Lee, et al. Effects of friedelin on the intestinal permeability and bioavailability of apigenin

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Keywords: Friedelin supplier, Cytochrome P450 (e.g. CYP17), inhibitors, activators


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