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FRAX1036

Cat. No. M13705
FRAX1036 Structure
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

FRAX1036 is a PAK inhibitor with Kis of 23.3 nM, 72.4 nM, and 2.4 μM for PAK1, PAK2 and PAK4, respectively.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 518.05
Formula
CAS Number 1432908-05-8
Purity >99%
Solubility DMSO 5.3 mg/mL
Storage at -20°C
References

[1] Di Han, et al. Future Med Chem. Computational insight into the mechanisms of action and selectivity of Afraxis PAK inhibitors

[2] Cristina Uribe-Alvarez, et al. Small GTPases. Targeting effector pathways in RAC1 P29S-driven malignant melanoma

[3] Vladislav Korobeynikov, et al. Breast Cancer Res Treat. Combined inhibition of Aurora A and p21-activated kinase 1 as a new treatment strategy in breast cancer

[4] Christina M Knippler, et al. Endocr Relat Cancer. MAPK- and AKT-activated thyroid cancers are sensitive to group I PAK inhibition

[5] Chudi O Ndubaku, et al. ACS Med Chem Lett. Design of Selective PAK1 Inhibitor G-5555: Improving Properties by Employing an Unorthodox Low-pK a Polar Moiety

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  Catalog
Abmole Inhibitor Catalog




Keywords: FRAX1036 supplier, PAK, inhibitors

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