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FR183998 free base

Cat. No. M15108
FR183998 free base  Structure
Size Price Availability Quantity
5mg USD 840  USD840 In stock
10mg USD 1420  USD1420 In stock
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Quality Control & Documentation
Biological Activity

FR183998 free base is a potent Na+/H+-exchange inhibitor, with IC50s of 0.3 nM, 3.1 nM and 6.5 nM by measurement of pHi change in rat lymphocytes, rat and human platelets, respectively.

Chemical Information
Molecular Weight 428.34
Formula C17H19Cl2N5O2S
CAS Number 239440-20-1
Solubility (25°C) DMSO ≥ 200 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Related Na+/H+ Exchanger (NHE) Products
NHE3-IN-1

NHE3-IN-1 is an inhibitor of sodium/proton exchanger 3 (NHE-3).

NHE3-IN-2

NHE3-IN-2 is a Na+/H+ exchanger 3 (NHE3) inhibitor.

Eniporide

Eniporide (EMD 96785) is a Na(+)/H(+) exchange (NHE) inhibitor.

Zoniporide hydrochloride hydrate

Zoniporide (CP-597396) hydrochloride hydrate is a potent and selective inhibitor of sodium-hydrogen exchanger type 1 (NHE-1). Zoniporide hydrochloride hydrate inhibits human NHE-1 (IC50=14 nM), and has >150-fold selectivity versus other NHE isoforms. Zoniporide hydrochloride hydrate potently inhibits ex vivo NHE-1-dependent swelling of human platelets (IC50=59 nM).

Zoniporide hydrochloride

Zoniporide (CP-597396) hydrochloride is a potent and selective inhibitor of sodium-hydrogen exchanger type 1 (NHE-1). Zoniporide hydrochloride inhibits human NHE-1 (IC50=14 nM), and has >150-fold selectivity versus other NHE isoforms. Zoniporide hydrochloride potently inhibits ex vivo NHE-1-dependent swelling of human platelets (IC50=59 nM).

  Catalog
Abmole Inhibitor Catalog




Keywords: FR183998 free base supplier, Na+/H+ Exchanger (NHE) , inhibitors, activators


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