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Forodesine hydrochloride

Cat. No. M10482
Forodesine hydrochloride Structure
Synonym:

BCX-1777 hydrochloride

Size Price Availability
25mg USD 252  USD280 Out of stock
50mg USD 450  USD500 Out of stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Forodesine hydrochloride is a potent and orally active transition-state analog inhibitor of purine nucleoside phosphorylase. Forodesine hydrochloride could induce apoptosis in leukemic cells by increasing the dGTP levels, acts as a potent human lymphocyte proliferation inhibitor. 

At a single dose of 10 mg/kg in mice, Forodesine elevates dGuo to approximately 5 μM. In the human peripheral blood lymphocyte severe combined immunodeficiency (hu-PBL-SCID) mouse model, Forodesine is effective in prolonging the life span 2-fold or more.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 302.71
Formula C11H15ClN4O4
CAS Number 284490-13-7
Purity >99%
Solubility Water 15 mg/mL
DMSO 9 mg/mL
Storage -20°C, sealed
References

Cutaneous T-cell lymphomas: Focusing on novel agents in relapsed and refractory disease
Lisa Argnani, et al. Cancer Treat Rev. 2017 Dec;61:61-69. PMID: 29102679.

The effects of forodesine in murine and human multiple myeloma cells
Liesbeth Bieghs, et al. Adv Hematol. 2010;2010:131895. PMID: 20981156.

Purine nucleoside phosphorylase inhibitor BCX-1777 (Immucillin-H)--a novel potent and orally active immunosuppressive agent
S Bantia, et al. Int Immunopharmacol. 2001 Jun;1(6):1199-210. PMID: 11407314.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Forodesine hydrochloride, BCX-1777 hydrochloride supplier, inhibitors

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