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Formoterol Hemifumarate

Cat. No. M5116
Formoterol Hemifumarate Structure
Synonym:

Eformoterol, CGP 25827A, NSC 299587, YM 08316

Size Price Availability Quantity
10mg USD 80 In stock
50mg USD 330 In stock
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Quality Control
Biological Activity

Formoterol causes dose-related inhibition of histamine-induced bronchoconstriction in conscious guinea-pigs.Formoterol, like salbutamol and salmeterol, relaxes isolated preparations of guinea-pig trachea and human bronchus, and inhibits antigen-induced mediator release from human lung fragments in a concentration-related fashion.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 402.40
Formula C19H24N2O4.1/2C4H4O4
CAS Number 43229-80-7
Purity >99%
Solubility DMSO 80 mg/mL
Water <1 mg/mL
Storage at -20°C
References

Formoterol on airway smooth muscle and human lung mast cells: a comparison with salbutamol and salmeterol.
Nials AT,et.al. Eur J Pharmacol. 1994 Jan 14;127-35. PMID: 8149969.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Formoterol Hemifumarate, Eformoterol, CGP 25827A, NSC 299587, YM 08316 supplier, Adrenergic Receptor, inhibitors

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