Formoterol causes dose-related inhibition of histamine-induced bronchoconstriction in conscious guinea-pigs.Formoterol, like salbutamol and salmeterol, relaxes isolated preparations of guinea-pig trachea and human bronchus, and inhibits antigen-induced mediator release from human lung fragments in a concentration-related fashion.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Solubility||DMSO 80 mg/mL;Water <1 mg/mL|
Formoterol on airway smooth muscle and human lung mast cells: a comparison with salbutamol and salmeterol.
Nials AT,et.al. Eur J Pharmacol. 1994 Jan 14;127-35. PMID: 8149969.
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