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Formoterol Hemifumarate

Cat. No. M5116
Formoterol Hemifumarate Structure
Synonym:

Eformoterol, CGP 25827A, NSC 299587, YM 08316

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
10mM*1mL in DMSO USD 50  USD50 In stock
5mg USD 40  USD40 In stock
10mg USD 65  USD65 In stock
50mg USD 240  USD240 In stock
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Quality Control & Documentation
Biological Activity

Formoterol causes dose-related inhibition of histamine-induced bronchoconstriction in conscious guinea-pigs. Formoterol, like salbutamol and salmeterol, relaxes isolated preparations of guinea-pig trachea and human bronchus, and inhibits antigen-induced mediator release from human lung fragments in a concentration-related fashion.

Chemical Information
Molecular Weight 402.40
Formula C19H24N2O4.1/2C4H4O4
CAS Number 43229-80-7
Solubility (25°C) DMSO 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Nials AT,et.al. Eur J Pharmacol. Formoterol on airway smooth muscle and human lung mast cells: a comparison with salbutamol and salmeterol.

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  Catalog
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Keywords: Formoterol Hemifumarate, Eformoterol, CGP 25827A, NSC 299587, YM 08316 supplier, Adrenergic Receptor, inhibitors, activators


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