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Folinic acid calcium salt

Cat. No. M2711
Folinic acid calcium salt Structure
Synonym:

Leucovorin

Size Price Availability Quantity
50mg USD 30  USD30 In stock
100mg USD 48  USD48 In stock
200mg USD 70  USD70 In stock
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Quality Control & Documentation
Biological Activity

Folic acid is an adjuvant compound used in cancer chemotherapy.

*The compound is unstable in solutions, freshly prepared is recommended



Product Citations
Chemical Information
Molecular Weight 511.50
Formula C20H21N7O7.Ca
CAS Number 1492-18-8
Solubility (25°C) Water ≥ 50 mg/mL
Storage 4°C, dry, protect from light, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Margherita Ratti, et al. Major innovations and clinical applications of disodium-levofolinate: a review of available preclinical and clinical data

[2] Muhammad Wasif Saif, et al. CoFactor: Folate Requirement for Optimization of 5-Fluouracil Activity in Anticancer Chemotherapy

[3] Shuna Sun, et al. Effects of methotrexate on the developments of heart and vessel in zebrafish

[4] L A Trissel, et al. Incompatibility of fluorouracil with leucovorin calcium or levoleucovorin calcium

[5] A G De Michelis, et al. The calcium salt of folinic acid for the treatment of deficiency anemia

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Keywords: Folinic acid calcium salt, Leucovorin supplier, Antifolate, inhibitors, activators


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