Flupenthixol dihydrochloride is a non-selective antagonist at D1 and D2 receptors. Flupenthixol dihydrochloride is a antagonist at dopamine (D1-D5), serotonin (5-HT2), adrenergic (α1) and histamine (H1) receptors. Flupenthixol dihydrochloride has antipsychotic properties in vivo. A single-blind, parallel group, general practice study was carried out in 153 patients with mild to moderate depression to compare the efficacy and tolerability of flupenthixol dihydrochloride and dothiepin hydrochloride. Both drugs were well tolerated, although persistence of anticholinergic side-effects in the dothiepin group resulted in a trend favouring flupenthixol. One patient in the flupenthixol group attempted suicide by overdose but made a complete recovery.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
Rapid assessment of choice between cocaine and food in rhesus monkeys: effects of environmental manipulations and treatment with d-amphetamine and flupenthixol.
Negus SS. Neuropsychopharmacology. 2003 May;28(5):919-31. PMID: 12637948.
Effects of remoxipride and some related new substituted salicylamides on rat brain receptors.
Hall H, et al. Acta Pharmacol Toxicol (Copenh). 1986 Jan;58(1):61-70. PMID: 2869639.
Depression in general practice: a comparison of flupenthixol dihydrochloride and dothiepin hydrochloride.
Dwivedi VS, et al. Curr Med Res Opin. 1990;12(3):191-7. PMID: 2272193.
|Related Dopamine Receptor Products|
Sulpiride is a dopamine D2-receptor antagonist. It has been used therapeutically as an antidepressant, antipsychotic, and as a digestive aid.
rac-Rotigotine Hcl is a high potency and selectivity agonist for D-2 receptor with Ki of 0.69 nM.
Promazine (hydrochloride) is a D2 dopamine receptor antagonist, belongs to the phenothiazine class of antipsychotics, used to treat schizophrenia.
|Prochlorperazine dimaleate salt
Prochlorperazine dimaleate is a dopamine (D2) receptor antagonist.
Pramipexole 2Hcl is a partial/full D2S, D2L, D3, D4 receptor agonist with a Ki of 3.9, 2.2, 0.5 and 5.1 nM for D2S, D2L, D3, D4 receptor, respectively.
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