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Fluo-8 AM

Cat. No. M15051
Fluo-8 AM  Structure
Size Price Availability Quantity
250μg USD 320  USD320 In stock
1mg USD 800  USD800 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity N/A
  • COA
  • MSDS
Biological Activity

Fluo-8 AM is a calcium fluorescent probe that can be loaded into protoplasts to detect calcium in apple flesh cells. The maximum excitation/emission wavelength is 495nm/516nm, which needs to be stored under -15℃ under light protection.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 1046.93
Formula C50H50N2O23
CAS Number 1345980-40-6
Purity N/A
Solubility DMSO:25 mg/ml
Storage -15°C, protect from light
References

[1] Lina Qiu, et al. Hortic Res. Loading calcium fluorescent probes into protoplasts to detect calcium in the flesh tissue cells of Malus domestica

[2] Thore Schade-Mann, et al. Hear Res. Calcium signaling in interdental cells during the critical developmental period of the mouse cochlea

[3] Andrea E Morrell, et al. Connect Tissue Res. Mechanosensitive Ca 2+ signaling and coordination is diminished in osteocytes of aged mice during ex vivo tibial loading

[4] Sebastian Rhl, et al. Science. ESCRT-dependent membrane repair negatively regulates pyroptosis downstream of GSDMD activation

[5] Noritaka Nakamichi, et al. Biol Pharm Bull. Screening to Identify Multidrug Resistance-Associated Protein Inhibitors with Neuroblastoma-Selective Cytotoxicity

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