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Fluensulfone

Cat. No. M9728
Fluensulfone Structure
Synonym:

MCW-2

Size Price Availability
5mg USD 150  USD150 4-7 Days
10mg USD 265  USD265 4-7 Days
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Quality Control & Documentation
Biological Activity

Fluensulfone is a new nematicide for chemical control of plant parasitic nematodes.

Chemical Information
Molecular Weight 291.70
Formula C7H5ClF3NO2S2
CAS Number 318290-98-1
Solubility (25°C) DMSO ≥ 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Kelly A Morris, et al. J Nematol. Efficacy of Various Application Methods of Fluensulfone for Managing Root-knot Nematodes in Vegetables

[2] James Kearn, et al. Pestic Biochem Physiol. Fluensulfone is a nematicide with a mode of action distinct from anticholinesterases and macrocyclic lactones

[3] Christian Strupp, et al. Toxicol Sci. Relationship of metabolism and cell proliferation to the mode of action of fluensulfone-induced mouse lung tumors: analysis of their human relevance using the IPCS framework

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Keywords: Fluensulfone, MCW-2 supplier, Anti-infection, inhibitors, activators


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