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Fludrocortisone acetate

Cat. No. M5652
Fludrocortisone acetate Structure

9α-Fludrocortisone acetate; 9α-Fluorcortisol acetate

Size Price Availability Quantity
100mg USD 60  USD60 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Fludrocortisone Acetate is a synthetic mineralocorticoid, used to control the amount of sodium and fluids in your body. It is used to treat Addison's disease by decreasing the amount of sodium that is lost (excreted) in your urine,also used to increase blood pressure.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 422.49
Formula C22H31FO6
CAS Number 514-36-3
Purity >98%
Solubility 45 mg/mL in DMSO
Storage at -20°C

[1] Fortunato JE, et al. J Pediatr Gastroenterol Nutr. Effect of fludrocortisone acetate on chronic unexplained nausea and abdominal pain in children with orthostatic intolerance.

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Keywords: Fludrocortisone acetate, 9α-Fludrocortisone acetate; 9α-Fluorcortisol acetate supplier, Mineralocorticoid Receptor, inhibitors

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