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FLLL32

Cat. No. M9142
FLLL32 Structure
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Quality Control
  • Current batch:
  • Purity >95%
  • COA
  • MSDS
Biological Activity

FLLL32 is a potent JAK2/STAT3 inhibitor with IC50 of <5 μM. FLLL32 is a small molecule analog of curcumin. It can inhibit signal transducer and activator of transcription-3 (STAT3). In the pSTAT3-positive A375 cell line, FLLL32 resulted in pro-apoptotic effects with an IC50 value of 1.3 μM at 48 hours. 

In an s.c. model of B16F10 melanoma in C57BL/6 mice, compared to the treatment with DMSO to the same animals, daily i.p. administration of FLLL-32 at concentrations of 25 mg/kg and 50 mg/kg significantly delayed tumor growth (p<0.001).

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 464.55
Formula C28H32O6
CAS Number 1226895-15-3
Purity >95%
Solubility DMSO: ≥ 60 mg/mL
Storage at -20°C
References

A novel small molecule inhibits STAT3 phosphorylation and DNA binding activity and exhibits potent growth suppressive activity in human cancer cells.
Lin L, et al. Mol Cancer. 2010 Aug 16;9:217. PMID: 20712901.

Novel STAT3 phosphorylation inhibitors exhibit potent growth-suppressive activity in pancreatic and breast cancer cells.
Lin L, et al. Cancer Res. 2010 Mar 15;70(6):2445-54. PMID: 20215512.

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Abmole Inhibitor Catalog 2017




Keywords: FLLL32 supplier, JAK, inhibitors

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