FITC-Dextran (MW 10000) is a fluorescent probe for fluorescein isothiocyanate (FITC) dextran (Ex=495 nm; Em=525 nm). FITC-Dextran (MW 10000) can be used as a marker to reveal heat shock-induced cell damage and to study the early and late stages of apoptosis. FITC-Dextran (MW 10000) can also be used for cell permeability studies, such as blood-brain barrier permeability and determination of the extent of blood-brain barrier disruption.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
|Solubility||Water 50 mg/mL|
|Storage||4°C, protect from light, dry, sealed|
|Related Fluorescent Dye Products|
Tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II) dichloride is an oxygen-sensitive fluorescence indicator widely used as a probe for luminescence detection and oxygen quantification. The maximum absorption wavelength is max 455 nm and the maximum luminescence is λmax 613 nm.
|FeRhoNox-1 (Fe2+ indicator)
FeRhoNox-1, also known as RhoNox-1, is an active fluorescent probe that specifically detects unstable iron (1) ions (Fe2+). After the reaction of -denier with Fe2+, -orange (red) fluorescent products are irreversibly generated. (Absmax= 540nm, FLmax= 575nm).
CMFDA is a cell-permeable fluorescent probe that can be used as a cellular tracer. CMFDA can be cleaved by non-specific esterases common to living cells, producing a fluorescent compound, fluorescein, visible using a fluorescent microscope.
Lyso-Tracker Red is an eosinophilic fluorescent probe with a maximum excitation wavelength of 577nm and a maximum emission wavelength of 590nm. Lyso-Tracker Red must be at very low concentrations (usually about 50nM) to achieve excellent selectivity.
ICG-OSu (ICG NHS ester) is a near infrared fluorescent agent with amine reactivity that is widely used in the design of in vivo imaging probes. Em >750 nm infrared, Ex >750 nm infrared.
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